Dr gundry’s protocol – apoe4.info wiki

Dr Steven Gundry Wikipedia GundryMD is a practitioner who applies his background as a cardiothoracic surgeon to his current functional medicine approach, which he calls restorative medicine. As a surgeon, he developed an expertise in xenotransplantation (the process of transplanting organs between members of different species). Among his surgical inventions is the world’s most widely used device to infuse heart tissue with a preservative solution. He is also a cum laude graduate of Yale University with special honors in human biological and social evolution. This background has given Dr Gundry unique insight into the body’s immune and genetic response.

Detailed information on his dietary recommendations can be found in his two books.


The first book “Diet Evolution: Turn off the genes that are killing you-and your waistline-and drop the weight for good” was published in 2008 and discusses the disconnect between today’s modern diet and the food that human genes need for healthy living. Dr Gundry subsequently stated that “Diet Evolution” was a compromise between what he prescribed at the time and what the publisher thought would sell; therefore, it is not a complete guide to his dietary advice. His second book “Plant Paradox: The Hidden Dangers in "Healthy" Foods That Cause Disease and Weight Gain” was published in 2017 by a different publisher who provided Dr Gundry more freedom to address his findings.

• Minimizes the body’s production of insulin through intermittent fasting accompanied by a moderate good carbohydrate, high good fat diet. See "Lowering Insulin Resistance" in Stavia’s Primer An Introduction to ApoE4, biochemistry, and possible prevention strategies. See Insulin Resistance See Blood Sugar . See Fasting insulin less than 5;_HgbA1c_less than 5.6

• Minimizes inflammation by eliminating/reducing the foods that have only “recently” been introduced to human genes: “recent” in evolutionary terms, as in the last 10,000 years when agriculture emerged. Many of these inflammatory foods contain lectins. Foods containing high lectin levels are beans and legumes, grains and grain products even if they are gluten free, and vegetables of the nightshade family. Ways to reduce lectinsSee Inflammation & LPS. See CRP less than 1.0; A/G greater than 1.8

The subject of lectins has been discussed numerous times on the ApoE4.info website. There are many who dismiss this dietary advice because, while there are studies, there’s no overwhelming scientifically collected evidence. Dr Gundry’s recommendation comes largely from his experience with tens of thousands of patients. Dr Gundry cites his own self-skepticism in Plant Paradox: “Believe me, twelve years ago I myself would have tossed this book out the window…” (page 70, hardcopy of "Plant Paradox"). So this skepticism is firmly based. Perhaps the rationale for this has to do with the fact humans have been eating high lectin foods for a number of years without obvious consequence. In his Plant Paradox Book, Dr Gundry explains that today’s environment is a lot different than that of our grandparents. It’s not just the lectins, it’s:

1. Our sensitivity to lectins has increased greatly due the recent introduction to chemical and other body disruptors, such as food additives, food preservatives, the introduction of NSAIDS pain pills in the early 1970’s, stomach acid reducers (Prilosec, Prevacid, Nexium) plastic food packaging/containers (like those containing BPA), petrochemical fertilizers introduced after World War II, herbicides, biocides, food that is now Genetically Modified (GMOs), skin-care products, hand sanitizers, on and on. These are compromising the body’s ability to deal with lectins. 2. We eat a lot more lectins today than in the past, largely because the dietary guidelines changed in 1980 resulting in greater carbohydrate consumption. Also, some foods today have been modified and consequently contain more lectins than in the past. 3. Lectin silently and slowly causes the body to attack itself, so except for those that are particularly sensitive, there’s no immediate, “if I eat a tomato, my rheumatoid arthritis flares up” effect.

• Avoids “bad” oils, i.e. those high in Omega-6 content, or high in Polyunsaturated Unsaturated Fatty Acids (PUFAs). PUFAs look for oxygen atoms to bond to, thereby producing oxidation in the body. Also avoids oils derived from lectins, e.g. peanut, or are that he refers to as “estrogen bombs” e.g. soybean oil. See Fats, Omega -3(ω-3) & -6(ω-6), DHA and More and Omega-3 fatty acids

Dr Gundry further modifies his dietary recommendations for ApoE4s. These recommendations are not found in either of his books, but have been gleaned from ApoE4s who are his patients and from the YouTube video AHS16 – Steven Gundry – Dietary Management of the Apo E 4. Many posts in the ApoE4.info forums discuss Dr Gundry. See Dr. Steven Gundry with diet recommendations for ApoE4 for initial familiarization.

• Supplement with fish oil. He cites that a high red blood count EPA + DHA (the two primary components of fish oil) corresponds with larger total brain and hippocampal volumes. He has stated that DHA in particular is what to emphasize, a person wants the most DHA per fish oil capsule that he/she can afford. While a good Omega-3 index for the general population is considered 8 to 10, Dr Gundry says the Omega-3 index for ApoE4s should be higher at 10 to 12.

• Supplement with grape seed extract, at least 100 mg/day. Grape seeds are rich in antioxidants and a compound called oligomeric proanthocyanidin complexes (OPCs). Proanthocyanidins are a class of polyphenols that boost hepatic NAD metabolism and SIRT1. Without going into details, SIRT1 expression is critical to understanding the many faceted effects of the ApoE4 gene. See Increase SirT1 function

• Supplement with turmeric. Best form is curcumin that is bioavailable. (Turmeric is the plant, curcumin is what is extracted from the turmeric). Curcumin has been found to activate SIRT1 and block the neurotoxicity of amyloid-beta in rat cortical neurons. In other words the curcumin was found to be neuroprotective. See Turmeric and curcuminarticle Turmeric and curcumin https://www.apoe4.info/wiki/Turmeric_and_curcumin. See Reduction of Aβ

• Avoid whole grain bread and whole grain products. While his dietary advice recommends eliminating all major sources of lectins, which includes all grain products, of particular interest to ApoE4s is his opinion about the lectin Wheat Germ Agglutinin (WGA). This is not gluten, it is found in the bran, so while white bread contains gluten, it does not contain WGA. In “Plant Paradox” he addresses many ill effects of WGA, but during the Q&A dinner session with the ApoE4.info meet-up group in August 2016, he made of point of addressing wheat germ agglutinin and how it can bind to sialic acids on your blood vessels and to insulin receptors. When the wheat germ agglutinin binds to insulin receptors in the muscles a person gets sarcopenia (aging muscle loss) and when it happens in the brain, it blocks the effect of insulin. As discussed in the page on Insulin Resistance, there is a significant link to brain insulin resistance and Alzheimer’s Disease. Dr Gundry thinks a lot of what we see as Alzheimer’s is is actually the accumulation through the years of wheat germ agglutinin.

Although they derived their findings through very different means, there are numerous overlaps in Dr Gundry’s and Dr Bredesen’s protocols. This coincidence did not go unnoticed by the ApoE4 community. In 2016, the ApoE4.info group introduced Dr Gundry and Dr Bredesen to each other. They each gave a presentation at the Ancestral Health Symposium and were able to exchange thoughts with each other at the group dinners each evening. The two have become good friends. Dr Bredesen is quoted on the back cover of Dr Gundry’s book “Plant Paradox” and Dr Gundry is quoted in the "Praise for the End of Alzheimer’s" section of Dr Bredesen’s book.

On August 21, 2017, Dr Gundry posted a video, Dr Steven Gundry interviews Dr Dale Bredesen about "The End of Alzheimer’s"the book that Dr Bredesen had just published. In the interview Dr Bredesen said, "In fact I’m actually starting phase one of your protocol right now myself, which I think is fantastic and actually fits very much with what we found in the test tube over the last 28 years on Alzheimer’s disease."